Abstract
Over the years, the oxidative ring enlargement of furfuryl alcohols, known as the
Achmatowicz reaction, has been developed into a powerful and versatile synthetic tool
for the preparation of 6-hydroxypyranones. This review provides a comprehensive collection
of the various ways to perform Achmatowicz rearrangement reactions and explores the
role of this ring-expansion process in contemporary organic synthesis.
1 Introduction
2 Classical Methods and Variants
3 Single-Electron-Transfer Oxidations
4 Metal-Catalyzed Ring Expansions
5 Photolytic Oxygenations
6 Enzymatic Transformations
7 Conclusions
Key words
Achmatowicz reaction - ring expansion - furan - pyranone - synthetic methodology -
heterocyclic chemistry
